Diagnostic criteria and problems in infective endocarditis. The duke criteria for the diagnosis of endocarditis provide a systematic approach for diagnosing both native valve endocarditis nve and pve. Click on the image or right click to open the source website in a new browser window. Its intracardiac effects include severe valvular insufficiency, which may lead to. Endocarditis is characterized by lesions, known as vegetations, which is a mass of platelets, fibrin, microcolonies. There are two major criteria for infective endocarditis. These images are a random sampling from a bing search on the term duke criteria for infectious endocarditis diagnosis. For the purposes of these guidelines, pve includes prosthetic valves of all types, annuloplasty rings, intracardiac patches and shunts. The purpose of this survey was to elaborate clinicians knowledge and opinion on relevant heart conditions as a duke minor criterion for the diagnosis of ie. The duke criteria are a set of clinical criteria set forward for the diagnosis of infective endocarditis. Prevention the endocarditis team diagnosis definition of the terms used in the esc 2015 modified criteria for diagnosis of ie, with modifications in main principles of prevention of infective endocarditis boldface 1. Antibiotic treatment of infec tious endocarditis depends on whether the involved valve is native or. Guidelines for the diagnosis and antibiotic treatment of. Hacek haemophilus species, aggregatibacter actinomycetemcomitans, cardiobac terium hominis, eikenella corrodens, and kingella kingae.
To assess the value and limitations of both vrc and dc for the diagnosis of ie, with special attention to the false negative results of duke criteria. Assesment of the duke criteria for the diagnosis of infective. Assesment of the duke criteria for the diagnosis of. Pdf proposed modifications to the duke criteria for the diagnosis. To compare vrc and dc in a large population of patients with proven endocarditis studied with tee. The first is a positive blood culture for endocarditis. How does this duke criteria for infective endocarditis calculator work. It comprises of 8 criteria divided in major and minor categories.
Negative predictive value of the duke criteria for. Clinical criteria for infective endocarditis requires. Histologic evidence of active endocarditis vegetation or intracardiac abscess or. Symptoms may include fever, small areas of bleeding into the skin, heart murmur, feeling tired, and low red blood cell count. Nov 26, 2016 there are two major criteria for infective endocarditis. The guidelines include native valve endocarditis nve and prosthetic valve endocarditis pve. Value and limitations of the duke criteria for the.
The cause of negative blood cultures was prior antibiotic treatment in 11 patients and q fever endocarditis detected by positive serology in three. Endocarditis will cause bacteremia and septic emboli. Among patients with infective endocarditis ie, inhospital mortality. Epidemiology, clinical manifestations, and diagnosis view in chinese contamination in the operating room. Negative predictive value of the duke criteria for infective. The endocarditis team should have meetings on a regular basis in order to discuss cases, take surgical decisions, and define the type of followup. Echocardiogram supportive of infective endocarditis. Pdf sensitivity and specificity of duke criteria for diagnosis of. Formal criteria to diagnose and stratify patients suspected of having infective. Moreover, changes in pathogen prevalence, in particular a more common. Jul 01, 2015 using the model of jones criteria for rheumatic fever, the duke criteria for infective endocarditis combine major and minor clinical criteria. Guidelines for the management of infective endocarditis.
Infective endocarditis is a potentially lethal disease that has undergone major changes in both host and pathogen. Infective endocarditis european society of cardiology. Modified dukes criteria for diagnosis of infective. Fulfilling the criteria, and a subsequently definitive diagnosis includes either having two major criteria, one major and three minor criteria, or five minor criteria. This page includes the following topics and synonyms. Proposed modifications to the duke criteria for the diagnosis.
Infective endocarditis is an infection of the inner surface of the heart, usually the valves. Bacterial endocarditis is a microbial infection of the endothelial surface of the heart. Negative predictive value of the duke criteria for infective endocarditis g. The duke criteria consists of 8 criteria 2 major and 6 minor which evaluates most common patient signs and symptoms to help with diagnosis of infective endocarditis.
For adequate diagnostic sensitivity, transesophageal echocardiography is the preferred modality used in patients designated highrisk or those in whom transthoracic echocardiography would likely be difficult. University of pennsylvania health system antimicrobial use. Microorganism demonstrated on culture or histology of vegetation or intracardiac abscess. An endovascular microbial infection of native heart valves that may be local cardiac including valvular. The task force for the management of infective endocarditis of the european society of cardiology escendorsed by. Value and limitations of the duke criteria for the diagnosis.
This is a pdf document titled modified dukes criteria for diagnosis of infective endocarditis. Duke criteria for infective endocarditis inflammatory heart. Two major criteria, or one major and three minor criteria, or five minor criteria. Positive blood culture results for ie and evidence of endocardial involvement from echocardiography, are the two major duke criteria. A definitive diagnosis of endocarditis can be made in patients with two major criteria, one major and three minor criteria, or five minor criteria.
To assess the value of each duke criteria for the diagnosis of infective endocarditis ie. Minor criterion includes predisposing heart condition or iv drug use, fever, vascular phenomena, immunologic phenomena, microbiological. The epidemiology of infective endocarditis has become more complex with todays myriad healthcareassociated factors that predispose to infection. Signs and symptoms of bacterial endocarditis are diverse. Endocarditis is an inflammation of the inner layer of the heart, the endocardium. Clinical criteria for possible endocarditis requires at least one major criterion and one minor criterion, or three minor criteria. Duke criteria for infective endocarditis calculator. Pathologic criteria are histological or culture confirmation ofpathologic criteria are histological or culture confirmation of vegetation or emboli. Diagnosis of infective endocarditis proposed modifications of duke criteria redefinition of possible ie echocardiographic minor criteria eliminated presence of s.
Although the sensitivity and specificity of the duke criteria for the diagnosis of infective endocarditis ie have been validated by investigators from europe and the united states, several shortcomings of this schema remain. Using the model of jones criteria for rheumatic fever, the duke criteria for infective endocarditis combine major and minor clinical criteria. Major criterion includes positive blood culture for typical infective endocarditis organisms, and echocardiogram with oscillating intracardiac mass. Pdf 2015 esc guidelines for the management of infective. Individual value of each of the duke criteria for the. Duke criteria for infective endocarditis durack dt, lukes as, bright dk. Infective endocarditis ie is an infection of the endocardial surface of the heart, which may include one or more heart valves, the mural endocardium, or a septal defect. Other structures that may be involved include the interventricular septum, the chordae tendineae, the mural endocardium, or the surfaces of intracardiac devices. This is a pdf document titled modified duke s criteria for diagnosis of infective endocarditis. Proposed modifications to the duke criteria for the diagnosis of infective endocarditis. The duke criteria for diagnosing infective endocarditis are specific.
Key difference acute vs subacute endocarditis infective endocarditis is a microbial infection of the heart valves or the mural endocardium that leads to the formation of vegetations composed of thrombotic debris and organisms often. Pdf proposed modifications to the duke criteria for the. Infective endocarditis guidelines on prevention, diagnosis. Pathologic criteria are histologic or culture confirmation of vegetation or emboli. Endocarditis diagnostic criteria modified duke criteria.
Nee operatiecatheterinterventie met prothesemateriaal voor aangeboren hartafwijking in afgelopen 6 maanden b. The duke criteria for endocarditis are summarized below. In the absence of classical features fever, cardiac murmur, and peripheral vascular stigmata the diagnosis of infective endocarditis ie may be. Mar 31, 2016 bacterial endocarditis is a microbial infection of the endothelial surface of the heart. European association for cardiothoracic surgery eacts, the european association of nuclear medicine eanm.
The duke ie database contains records collected prospectively on 800 cases of definite and possible ie since 1984. The focus is put on infectious causes, the possible pathogen agents and on the presence of ekg modifications. Ralph corey, md, joseph kisslo, md, and the duke endocarditis service with use of new duke criteria, 405 episodes of sus. It is the dedication of healthcare workers that will lead us through this crisis. Temporal evolution of knowledge made possible important advances in diagnostic techniques, specially in echocardiography, the possibility of cardiac surgery during the active infeccious process and new guidelines for antibiotic prophylaxis before interventional procedures. The duke criteria for infective endocarditis provides standardized diagnostic criteria for endocarditis. Infective endocarditis was a fatal disease three generations ago. Proposed modifications to the duke criteria for the diagnosis of infective endocardi tis. Duke criteria for infective endocarditis radiology. The endocarditis team chooses the type, duration, and mode of followup of antibiotic therapy. Many studies have now demonstrated the superiority of the duke. This is a health tool that helps clinicians diagnose infective endocarditis, a condition that is quite challenging to diagnose.
Major duke criteria diagnose and management of infective endocarditis vegetations detected in 67% of definite cases by duke criteria irregular shape occur on lowpressure side of turbulent jet atrial side in mitral and tricuspid regurgitation ventricular side in aortic and pulmonic regurgitation. Sexton,2,3 nathan mick,3 richard nettles,3 vance g. Duke criteria for infectious endocarditis diagnosis, endocarditis diagnosis, modified duke criteria for infectious endocarditis. Evaluation of new clinical criteria for the diagnosis of infective. For adequate diagnostic sensitivity, transesophageal echocardiography is the preferred modality used in patients designated highrisk or those in whom transthoracic. These were originally proposed in 1994 to help establish the diagnosis of endocarditis. Tee recommended as first test in the following patients. Nowadays, the duke criteria are the clinical gold standard diagnostic test though obviously, pathology is the true gold standard but note that the duke criteria are certainly not completely sensitive and may be nonspecific, depending on the case. Diagnostic criteria and problems in infective endocarditis ncbi. Clinical criteria for definite endocarditis requires two major criteria, or one major and three minor criteria, or five minor criteria. Suspect ie and consider the duke criteria in patients with. Excludes single positive cultures for coagulasenegative staphylococci and organisms that do not cause endocarditis.
Clinical criteria are 2 major, 1 major plus 3 minor or 5 minor criteria e. Complications may include backward blood flow in the heart, the heart struggling to pump a sufficient blood to meet the bodys needs heart failure, abnormal electrical. Pdf background the duke criteria represented a major advance in the diagnosis of infective endocarditis ie by formally incorporating. Nov 25, 2016 the term predisposing heart condition is used as an indication of antimicrobial prophylaxis to prevent infective endocarditis ie and as a criterion for diagnosing ie according to modified duke criteria. Pdf although the sensitivity and specificity of the duke criteria for the diagnosis of infective endocarditis ie have been validated by. Ralph corey2,3 from the divisions of 1cardiology and 2infectious diseases, and departments of 3medicine and 4pediatrics, duke university. Modified dukes criteria for infective endocarditis. Key difference acute vs subacute endocarditis infective endocarditis is a microbial infection of the heart valves or the mural endocardium that leads to the formation of vegetations. Duke criteria for infectious endocarditis diagnosis. The modified duke criteria are a set of clinical criteria set forward to establish the diagnosis of infective endocarditis. Difference between acute and subacute endocarditis key.
Duke criteria for the diagnosis of endocarditis definite. New criteria for diagnosis of infective endocarditis. The term predisposing heart condition is used as an indication of antimicrobial prophylaxis to prevent infective endocarditis ie and as a criterion for diagnosing ie according to modified duke criteria. Definitions a microbial infection of a cardiac valve or the endocardium caused by bacteria, fungi, or chlamydia often categorized as acute or s ubacute based on the rapidity of the clinical course alternatively described by type of risk factor e. The systematic diagnosis of ie is based on the duke classification4,5 that. Modification of the diagnostic criteria proposed by the duke endocarditis service to permit improved diagnosis of q fever endocarditis. Endocarditis diagnostic criteria duke criteria calculator. Infective endocarditis symptoms, treatment, overview mims. Difference between acute and subacute endocarditis. The endocarditis diagnostic duke criteria calculator evaluates both major and minor diagnostic criteria.
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